NexGard Spectra vs NexGard: Which One Does Your Dog Really Need?

11th Dec 2025

If you’re trying to choose between NexGard and NexGard Spectra, you’re not alone. Many pet owners feel confused about how they differ. So what’s the difference between NexGard and NexGard Spectra? In short, both protect your dog from fleas and ticks, but NexGard Spectra goes a step further by also protecting against intestinal worms and heartworm. Below, we break down both options clearly so you can choose the right fit for your dog’s health, lifestyle and environment.

What Is NexGard?

NexGard is a monthly, chewable flea and tick treatment designed to protect dogs from:

  • Fleas
  • Paralysis ticks
  • Brown dog ticks
  • Bush ticks

Its active ingredient, Afoxolaner, works quickly to kill parasites before they can cause harm. NexGard is often recommended for dogs who need reliable flea and tick protection without additional internal parasite coverage.

Common Uses

  • Monthly flea prevention
  • Monthly tick control
  • Dogs living in high-tick areas

Side Effects

Most dogs tolerate NexGard well, but possible side effects include:

  • Vomiting
  • Diarrhoea
  • Lethargy
  • Itching

If your dog has a history of seizures, always check with your vet before starting any isoxazoline-based product.

Dosage

NexGard is given once per month, with tablet sizes based on your dog’s weight. Your vet or dosage chart will guide you.

What Is NexGard Spectra?

NexGard Spectra for dogs offers all the flea and tick protection of NexGard, but with added defence against:

  • Heartworm
  • Roundworm
  • Hookworm
  • Whipworm
  • Lungworm
  • Fleas and ticks (same coverage as NexGard)

This broader protection is thanks to its second active ingredient, Milbemycin Oxime.

Common Uses

  • Dogs that need an all-in-one parasite treatment
  • Owners who prefer one chew instead of multiple preventatives
  • Dogs spending time around other pets, daycare or parks where worm exposure is higher

Side Effects

Like NexGard, side effects are uncommon but may include:

  • Vomiting
  • Soft stools
  • Loss of appetite
  • Lethargy

Most symptoms are mild and temporary. Always contact your vet if anything seems unusual.

Dosage

NexGard Spectra is also given monthly based on weight. Because it prevents heartworm, it’s crucial not to skip doses.

What’s the Difference Between NexGard and NexGard Spectra?

Here’s the simplest breakdown:

Feature

NexGard

NexGard Spectra

Kills fleas

Kills ticks

Prevents heartworm

Treats intestinal worms

Active ingredients

Afoxolaner

Afoxolaner + Milbemycin Oxime

Monthly chew

Suitable for

Dogs who only need flea/tick prevention

Dogs needing broader internal + external parasite protection

The primary difference between NexGard and NexGard Spectra is the coverage of internal parasites. NexGard is external-only. NexGard Spectra is a comprehensive treatment that targets both external pests and internal worms, including heartworm.

Which One Should You Choose?

Choose NexGard if:

  • Your dog only needs flea and tick protection
  • You already use a separate heartworm preventative
  • Your dog has a sensitive stomach and does better with fewer active ingredients

Choose NexGard Spectra if:

  • You want full parasite protection in one chew
  • You prefer a simple, single-product routine
  • Your dog spends time outdoors, socialises often, or lives in a worm-prone area

Both products are safe, effective and vet-recommended. The best choice depends on your dog’s lifestyle and your parasite protection preferences.

Where to Buy NexGard and NexGard Spectra

At The Animal Pharmacy, we stock competitively priced parasite preventatives, including NexGard and NexGard Spectra for dogs, with fast, reliable delivery across Australia.

If you’re still unsure which product suits your dog best, our team is always here to help you make an informed, confident choice.