Apoquel for Dogs: Use, Side Effects, and Dosage
11th Dec 2025

If your dog is constantly scratching, biting at their skin, or struggling with chronic allergies, you’ve likely heard of Apoquel. Many pet owners turn to this medication for fast, reliable itch relief, but understanding how it works, how long to use it, and what to expect is essential.
In this guide, we’ll explain everything you need to know, including how many days should a dog take Apoquel, the Apoquel tablets for dogs dosage, and Apoquel tablets for dogs side effects, so you can make confident, informed decisions about your pet’s care.
What Is Apoquel?
Apoquel (oclacitinib maleate) is a fast-acting anti-itch medication used primarily for dogs with allergic dermatitis and atopic dermatitis. Unlike traditional medications that simply mask the irritation, Apoquel works by targeting the specific pathways in the dog’s immune system that cause itch and inflammation.
It is not a steroid, which means it generally avoids many long-term steroid-related complications. Apoquel is manufactured through tightly controlled pharmaceutical processes to ensure consistency, purity, and safety for veterinary use.
Most dogs begin to experience relief within 4 hours, with itch reduction often visible within 24 hours, which is one of the reasons why Apoquel is widely recommended by veterinarians.
What Conditions Does Apoquel Help With?
Apoquel may be prescribed for:
- Environmental allergies (grass, dust mites, pollens)
- Food allergies
- Flea allergy dermatitis
- Contact allergies
- Chronic atopic dermatitis
While it reduces itch and inflammation, it does not cure the underlying cause of allergies. Instead, it helps manage symptoms, allowing your dog to feel more comfortable while your vet works to identify the triggers.
How Many Days Should a Dog Take Apoquel?
One of the most common questions is: How many days should a dog take Apoquel?
Dogs typically start with a loading dose – twice daily for up to 14 days, depending on your veterinarian’s instructions. After the initial period, most dogs switch to a once-daily maintenance dose long-term.
The length of treatment depends entirely on your dog’s condition. Dogs with chronic allergies may need Apoquel as an ongoing therapy, while dogs with short-term flare-ups may only require it for a few weeks. Always follow your vet’s guidance and never adjust the duration yourself.
Apoquel Tablets for Dogs Dosage
Your veterinarian will tailor the exact amount based on your dog’s weight. Below is the standard guideline:
Dosage Table (Apoquel Tablets for Dogs Dosage)
|
Dog Weight (kg) |
Loading Dose (Twice Daily) |
Maintenance Dose (Once Daily) |
|
3.6 – 5.4 kg |
3.6 mg |
3.6 mg |
|
5.5 – 10.9 kg |
5.4 mg |
5.4 mg |
|
11 – 20 kg |
16 mg |
16 mg |
|
20.1 – 40 kg |
16 mg |
16 mg |
|
40.1 – 60 kg |
16 mg + 3.6 mg |
16 mg + 3.6 mg |
These values are approximations. Your vet’s prescription always overrides any general guideline.
Apoquel Tablets for Dogs Side Effects
Apoquel is generally well-tolerated, but like any medication, it can have side effects. The most commonly reported Apoquel tablets for dogs side effects include:
- Mild vomiting or diarrhoea
- Lethargy
- Increased susceptibility to infections
- Skin infections such as demodicosis (rare)
Less common but more serious side effects may occur in dogs with underlying immune conditions or cancer. This is why veterinary supervision is important, especially for long-term use.
If your dog experiences worsening symptoms, extreme lethargy, persistent digestive upset, or the development of new lumps or bumps, contact your veterinarian promptly.
Is Apoquel Safe and Effective for Dogs?
For most dogs, yes. Apoquel is considered both safe and effective when used as directed. It offers fast relief, improves quality of life, and reduces the stress that chronic itching can cause. Many veterinarians prefer Apoquel for long-term allergy management because it strikes a balance between effectiveness and tolerability.

Where to Buy Apoquel
Apoquel is a prescription-only medicine, meaning it is not available over the counter. If your veterinarian has recommended it, you can order Apoquel for dogs through The Animal Pharmacy using a valid prescription.
Helping You Make the Best Choice for Your Best Friend
Chronic itching can leave your dog uncomfortable and leave you feeling helpless. Apoquel provides rapid, targeted relief for many allergy-related conditions, but understanding how many days should a dog take Apoquel, proper Apoquel tablets for dogs dosage, and possible Apoquel tablets for dogs side effects ensures your dog gets the safest, most effective care.
When you’re ready, The Animal Pharmacy is here to help supply your dog’s medication safely, affordably, and with the care your pet deserves.